AVIRULENT VACCINE AGAINST RABIES, STRAIN OF RABIES VIRUS USED FOR PREPARING VACCINE AGAINST RABIES AND METHOD OF ITS PREPARING

摘要

FIELD: medicine, virology. SUBSTANCE: vaccine has avirulent mutant strain SAD Berne of rabies virus. Strain has a natural glutamic acid at position 333 codon of which is distinct from arginine codons by at least two nucleotides. Strain is deposited in National Collection of microorganism cultures at number C.N.C.M. N 1-1238. Strain is obtained by selection using monoclonal antibodies that neutralize strains SAD and TAG1. Invention can be used for preparing an agent used for specific prophylaxis of rabies. EFFECT: enhanced safety and effectiveness of strain and vaccine. 5 cl, 5 dwg