| 发明名称 | Methods and compound to inhibit Ca<sup>2+</sup> permeable cation conductance | ||
| 摘要 | The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof. | ||
| 申请公布号 | US9211313(B2) | 申请公布日期 | 2015.12.15 |
| 申请号 | US201213351611 | 申请日期 | 2012.01.17 |
| 申请人 | The Research Foundation of State University of New York;Beth Israel Deaconess Medical Center | 发明人 | Sachs Frederick;Gottlieb Philip;Suchyna Thomas;Alper Seth L.;Vandorpe David H.;Xu Chang |
| 分类号 | A61K38/16;A61K38/17 | 主分类号 | A61K38/16 |
| 代理机构 | Hodgson Russ LLP | 代理人 | Hodgson Russ LLP |
| 主权项 | 1. A method of reducing deoxygenation induced calcium and cation permeable conductance of red blood cells of an individual who has sickle cell anemia comprising exposing the red blood cells of the individual who has been identified as having sickle cell anemia to a composition comprising an amount of an isolated or synthesized peptide comprising the sequence of SEQ ID NO: 1 that is effective to reduce deoxygenation induced calcium and cation permeable conductance of the red blood cells. | ||
| 地址 | Amherst NY US | ||