Treatments of disease or disorders using nanoparticles for focused hyperthermia to increase therapy efficacy

摘要

Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy. Methods for treating a target area may comprise systemically introducing nanoparticles into an organism; allowing the nanoparticles to preferentially accumulate in the target area, applying an external energy where the nanoparticles are adapted to transduce at least a portion of the external energy into a heat energy so as to create a focused localized hyperthermia; and applying a subsequent additional therapy.

主权项

1. A method for the treatment of a tumor residing in a target area of an organism comprising:
introducing a plurality of nanoparticles into a circulating blood of an organism; allowing the nanoparticles to preferentially accumulate in the target area; applying an external energy to the target area wherein the nanoparticles are adapted to transduce at least a portion of the external energy into heat energy, wherein the external energy is electromagnetic energy; wherein the electromagnetic energy is selected from the group consisting of ultraviolet light, visible light, infrared light, microwaves, and a combination thereof; wherein the heat energy causes a rise in temperature in the target area; allowing the temperature of the target area to elevate to a localized elevated temperature by way of a transduction of the external energy into heat energy by the nanoparticles, wherein the localized elevated temperature is non-ablative, wherein the localized elevated temperature increases perfusion and/or reduces hypoxia of the tumor; and applying ionizing radiation to the target area at a time during the increased perfusion and/or the reduced hypoxia.