| 摘要 |
medicine. SUBSTANCE: described are new benzylpiperidine derivatives of formula I: wherein R1 is H or Hal; R2 is unsubstituted or substituted Hal in aromatic ring, benzyl group in position 2,3 or 4 of piperidine ring, provided that R2 is other than 4- benzyl when X is -CO; Y and Z are CH2, and R1 is H; R3 is H or A, X is CO, Y is CO, Y is CH2, NH or -0- is CH2 or bond; A is C1-6 alkyl, B is O, H+OH, Hal is F, Cl, Ar or J, and also salts thereof. Compounds of formula I have inhibiting activity with respect to binding sigma receptors and are useful for treating neurodegenerative diseases. EFFECT: improved properties of the title compounds. 6 cl, 11 ex, 1 tbl |
