Patch for treatment of eyelid disease containing clobetasol

摘要

A patch for treatment of eyelid diseases that is provided with a support, a pressure-sensitive adhesive layer, and a release layer in this order, wherein (a) the pressure-sensitive adhesive layer includes the following (a-1) to (a-4): (a-1) a styrene-isoprene-styrene block copolymer, a tackifier resin, and a softening agent are contained; (a-2) a ratio (mass ratio) of the styrene-isoprene-styrene block copolymer and the tackifier resin is 1:2 to 1:4; (a-3) a content of the softening agent is 40% to 60% by mass; and (a-4) further 0.005% to 5% by mass of clobetasol or acid ester thereof is contained; and (b) the support has elastic modulus with a Young's modulus of 0.01 to 0.5 GPa: and a method for producing the patch for treatment of eyelid diseases including: forming a pressure-sensitive adhesive layer on a upper surface of a release layer.

主权项

1. A patch for treatment of eyelid diseases, comprising a support, a pressure-sensitive adhesive layer, and a release layer in this order, wherein
(a-1) the pressure-sensitive adhesive layer includes a styrene-isoprene-styrene block copolymer, a tackifier resin, and a softening agent; (a-2) a mass ratio of the styrene-isoprene-styrene block copolymer and the tackifier resin in the pressure-sensitive adhesive layer is 1:2 to 1:4; (a-3) a content of the softening agent in the pressure-sensitive adhesive layer is 40% to 60% by mass; and (a-4) the pressure-sensitive adhesive layer further comprises 0.005% to 5% by mass of clobetasol or acid ester thereof; (b) the support has elastic modulus with a Young's modulus of 0.01 to 0.5 GPa; (c) the styrene-isoprene-styrene block copolymer has a styrene content of 15% or more by mass and a diblock content of 30% or less by mass; and (d) the support is a polyethylene film with a thickness of 1 to 80 μm.