Dressing compositions and methods

摘要

Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.

主权项

1. A wound dressing, comprising
a first component comprising an eight arm hydrophilic polymer with thiol terminated ends; and a second component comprising a cross-linker, said cross-linker comprising a thiopyridine terminated polyethylene glycol and forming reversible disulfide cross-linkages with the thiol terminated ends of the hydrophilic polymer; wherein the first and second components react to form a uniform layer that adheres to skin of a mammal and acts as a wound dressing.