Carrier-linked magnetic nanoparticle drug delivery composition and method of use

摘要

The present invention is a targeted drug delivery composition composed of carrier-linked magnetic nanoparticles. Using an alternating magnetic field, nanoparticles bound to a targeted cell are selectively ruptured thereby releasing therapeutic agents at the desired site of action.

主权项

1. A method for providing a therapeutic agent to a subject comprising administering to a subject in need thereof a carrier-linked magnetic nanoparticle containing a therapeutic agent and a targeting moiety attached to the carrier-linked magnetic nanoparticle, wherein the carrier is a liposome and the therapeutic agent is encapsulated within the carrier-linked magnetic nanoparticle, and wherein the application of an alternating magnetic field to the subject causes liposomes bound to a target cell in the subject to rupture and release therapeutic agent, while unbound liposomes remain intact, thereby providing the therapeutic agent to the subject.