Method for treating defective dura mater

摘要

Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer. Further, above the hydrophobic electrospun layer, there can be at least one hydrophilic electrospun layer. A transition layer can be further included between the hydrophobic and the hydrophilic electrospun layers. Additionally, cytokines and/or medicines can be affixed to either or both of the hydrophobic and the hydrophilic electrospun layers, by way of bio-printing. The disclosed artificial dura mater shows good biocompatibility, enhances dural tissue regeneration, achieves excellent repairing effects, prevents adhesion, allows complete absorption, has good mechanical properties, ensures low infection rates, and can be loaded with therapeutic agents.

主权项

1. A method of treating a subject having a defective dura mater, comprising implanting an artificial dura mater proximate to said defective dura mater in the brain of said subject, wherein said artificial dura mater consists essentially of synthetic materials and comprises at least a hydrophobic and biodegradable electrospun layer comprising 30% or more polylactic acid (PLA), and wherein said hydrophobic electrospun layer comprises fibers with a diameter of 50-1000 nm and pores with a size of less than 3 μm, wherein said hydrophobic and biodegradable electrospun layer is placed proximate to the brain surface.