发明名称 |
Trail collectin fusion proteins |
摘要 |
The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications. |
申请公布号 |
US9212211(B2) |
申请公布日期 |
2015.12.15 |
申请号 |
US201414322830 |
申请日期 |
2014.07.02 |
申请人 |
APOGENIX GMBH |
发明人 |
Hill Oliver;Gieffers Christian;Thiemann Meinolf;Branschädel Marcus |
分类号 |
C07K14/525;C07K14/42;C07K14/47;C12N15/62 |
主分类号 |
C07K14/525 |
代理机构 |
Perkins Coie LLP |
代理人 |
Perkins Coie LLP ;Kung Viola T. |
主权项 |
1. A fusion protein comprising:
(i) TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) or a receptor binding domain thereof, and (ii) a collectin trimerization domain comprising a neck domain or a neck and carbohydrate binding domain of surfactant protein-D, wherein (ii) is located C-terminally of (i). |
地址 |
Heidelberg DE |