| 发明名称 | Composition and method for treating HPV | ||
| 摘要 | Described are lyophilized compositions comprising cidofovir, hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and, optionally, a plasticizer. In particular, described are such compositions that form a sheet-shaped porous solid matrix. Also described are methods for producing such compositions and their use in treating human papillomavirus (HPV) infections and HPV-associated malignancies, in particular, HPV lesions and cervical cancer. | ||
| 申请公布号 | US9211338(B2) | 申请公布日期 | 2015.12.15 |
| 申请号 | US201214232529 | 申请日期 | 2012.07.13 |
| 申请人 | Universite Libre de Bruxelles;Mithra Pharmaceuticals S.A. | 发明人 | Piette Marie;Evrard Brigitte;Coïa Isabelle |
| 分类号 | A61K9/14;A61K47/38;A61K9/00;A61K9/19;A61K31/675;A61K9/06;A61K9/70 | 主分类号 | A61K9/14 |
| 代理机构 | TraskBritt, P.C. | 代理人 | TraskBritt, P.C. |
| 主权项 | 1. A sheet-shaped lyophilized composition comprising: (a) cidofovir in an amount between 0.1 and 5 mg/cm2; (b) hydroxyethylcellulose (HEC) or hydroxypropylmethylcellulose (HPMC) in an amount between 1 and 17 mg/cm2; and, optionally, (c) a plasticizer in an amount between 0 and 5 mg/cm2. | ||
| 地址 | Brussels BE | ||