发明名称 |
DOBBELT-STRENGEDE RIBONUKLEINSYRER MED ROBUST FYSISK-KEMISK STRUKTUR OG HØJSPECIFIK BIOLOGISK AKTIVITET |
摘要 |
<p>The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsRNA) having specific biological activities, which includes acting as a selective agonist for activation of the Toll-like receptor 3. Its "rugged" molecular structure as measured by physico-chemical techniques is resistant to molecular unfolding (i.e., denaturation). This structure appears to be responsible for increased efficacy of dsRNA in therapeutic applications and improved biological activity (e.g., used as an immunoregulatory agent). Medicaments, processes for their manufacture, and methods for their use are provided herein.</p> |
申请公布号 |
DK2340307(T3) |
申请公布日期 |
2015.12.14 |
申请号 |
DK20090822342T |
申请日期 |
2009.10.23 |
申请人 |
HEMISPHERX BIOPHARMA, INC. |
发明人 |
STRAYER, DAVID;CARTER, WILLIAM, A. |
分类号 |
C12N15/117;A61K31/713 |
主分类号 |
C12N15/117 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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