| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions relates to field of medicine and pharmacology and deals with isolated specifically binding human PCSK9 antibody, which contains : hypervariable part of variable area of heavy chain 1 (VH CDR1) with amino acid sequence, demonstrated in SEQ ID NO: 6; VH CDR2 with amino acid sequence, demonstrated in SEQ ID NO: 7; VH CDR3 with amino acid sequence, demonstrated in SEQ ID NO: 8 or 9, and additionally containing:CDR1 of variable area of light chain (VL) with amino acid sequence, demonstrated in SEQ ID NO: 10; VL CDR2 with amino acid sequence, demonstrated in SEQ ID NO: 11; and VL CDR3 with amino acid sequence, demonstrated in SEQ ID NO: 12, as well as antibody, coded by plasmids, deposited in American Type Culture Collection (ATCC) and having number in ATCC No. PTA-10547 or PTA-10548 and PTA-10549, where said antibody specifically binds human PCSK9, and method of reducing level of low density lipoprotein cholesterol in subject's blood, including antibody introduction.EFFECT: group of inventions provided prolonged action of antibodies in treatment of hypercholesterolemia.10 cl, 5 ex, 9 tbl, 15 dwg |
