METHOD FOR TREATING CANCER PATIENTS USING FOLR1 TARGETED DRUG AND ANTIFOLATE, AND DRUG

摘要

The present invention provides a method for treating cancer using a human folate receptor α (referred to herein as FOLR1) targeted drug by increasing the expression of FOLR1 using an antifolate, a cancer drug including a human FOLR1 targeted drug for increasing the expression of FOLR1 using an antifolate, and a method for enhancing the therapeutic effect of a human FOLR1 targeted drug by increasing the expression of FOLR1 in cancer cells using an antifolate. For example, the present invention provides a more effective method of treatment for cancer patients having a low FOLR1 expression level in whom the antitumor activity of human FOLR1 targeted drugs is not adequately manifested, and cancer patients who express FOLR1 but desire enhanced cancer treatment, by the concomitant use of an antifolate and a human FOLR1 targeted drug.