| 摘要 |
The present invention relates to a novel bipolar aryl vinyl compound, nano-probe particles including the same, a contrast agent using the same, and an imaging method thereof. The novel bipolar aryl vinyl compound can adjust the solid-state fluorescence (SSF) color according to donor-acceptor combinations and shows a hydrodynamic size less than 65 nm in an aqueous environment as well as exhibiting increased aggregation-enhanced fluorescence (AEF) and SSF. The nano-probe particles have a hydrodynamic size less than 25 nm, show increases SSF in a near-infrared (NIR) range of 650 nm and higher, and are accumulated in cells of a specific tissue such as the sentinel lymph node, brain, or tumors or on an in vivo level to detect the tissue specifically. The contrast agent and the imaging method can specifically contrast lymph nodes, tumors, or brain tissues to be applied effectively to the diagnosis of cancer, tumors, and brain diseases. |
