PYRIDOXINE DERIVATIVE-BASED BETA-ADRENERGIC BLOCKING AGENTS

摘要

FIELD: chemistry.SUBSTANCE: invention relates to synthetic biologically active substances of the heterocyclic series, having high antiadrenergic activity, which are beta-substituted alcohols containing a pyridoxine fragment of general formula 1:, where: 1a R+R=-C(CH)R=NHCH(CH); 1b R+R=-C(CH)R=NHC(CH);1c R+R=-C(CH)R=NHCH; 1d R+R=-C(CH)R=NHC(CH)CHCH; 1e R+R=-C(CH)R=N(CHCH)O; 1f R+R=-C(CH)R=N(CHCH)CH; 1g R+R=-C(CH)R=OCH(CH); 1h R+R=-C(CH)R=OCHCH; 1i R=H, R=HR=OH;1j R+R=-CH(CH), R=NHCH(CH); 1k R+R=-CH(CH), R=NHC(CH); 1l R+R=-CH(CH), R=NHC(CH)CHCH; 1m R+R=-CH(CH), R=N(CHCH)O; 1n R+R=-CH(CH), R=N(CHCH)CH; 1o R+R=-CH(CH), R=OCHCH.EFFECT: compounds of general formula 1 have high efficiency and duration of antiadrenergic properties with a short time for the onset of the effect and low toxicity.2 dwg, 20 ex