| 摘要 |
PROBLEM TO BE SOLVED: To provide biglycan mutants and related therapeutics and methods of use.SOLUTION: The disclosure provides biglycan-related therapeutic polypeptides having substitution at two serine residues not to comprise any glycosaminoglycan side chain. Further provided is a method for treating diseases and conditions associated with biglycan of abnormal level or activity, for example, disorders associated with unstable cytoplasmic membrane, for example, due to the unstable dystrophin-associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including disorders resulting from abnormal MuSk activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies such as Dechenne's Muscular Dystrophy and Becker's Muscular Dystrophy, neuromuscular disorder and neurological disorders. |
