| 发明名称 |
METHODS FOR IMPROVING SAFETY OF BLOOD-BRAIN BARRIER TRANSPORT |
| 摘要 |
The present disclosure relates to compositions and methods for improving the safety of blood-brain barrier receptor-mediated blood-brain barrier transport. |
| 申请公布号 |
US2015353639(A1) |
申请公布日期 |
2015.12.10 |
| 申请号 |
US201314761895 |
申请日期 |
2013.05.20 |
| 申请人 |
Genentech, Inc. |
发明人 |
Watts Ryan Jefferson;Yu Zuchero Joy;Couch Jessica;Dennis Mark |
| 分类号 |
C07K16/28;C07K16/46;A61K39/395;A61K47/48;C07K16/44;A61K35/18;C07K16/40 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of transporting a compound across the blood-brain barrier in a subject comprising exposing an antibody which binds with low affinity to a blood-brain barrier receptor (BBB-R) coupled to a compound to the blood-brain barrier such that the antibody transports the compound coupled thereto across the blood-brain barrier, wherein reduction of red blood cell levels in the subject upon antibody administration to the subject is decreased or eliminated. |
| 地址 |
South San Francisco CA US |
