| 主权项 |
1. Compound of the following formula (I):(I)
characterized in that, R1 is a C1-C6 alkyl group, a —NR4R5 group, or an —OR6 group, R4, R5 and R6 are independently a hydrogen atom, and/or C1-C6 alkyl group, X is chosen from a group consisting of:
—C*(R7R8)-N(R9)-C(R10R11)-,—C*(R7R8)-N(R9)-C(O)—,—C*(R7R8)N(R9)-,—C*(R7R8)O—,—O*C(R7R8)-,—C*(R7R8)S—,—S*C(R7R8)-,—C*(R7R8)C(R9R10)-,—C*(O)NH—,—C*(S)NH—,—C*(R7)=C(R8)-,—C*(R7)=N—, and—N*(R7)-C(R8R9)-C(R10R11)-wherein R7, R8, R9, R10 and R11 are independently a hydrogen atom, and/or C1-C6 alkyl, and the atoms labeled with a “*” are linked to the carbon labeled with a “*” in formula (I), R2 is a hydrogen atom, a C1-C6 alkyl group or a halogen atom, Y is chosen from a group consisting of HNC(O), HNC(S), HNSO2, HNC(O)CH2, HNC(S)CH2, HNC(O)NH, HNC(S)NH, CH2NHC(O), C(O)NH, CH2NHC(S) and C(O)NHCH2, and R3 is chosen from a group consisting of:
an aryl, group mono or polysubstituted with:
a hydroxyl,a halogen,a C1-C6 alkyl-amine,a C1-C6 alkoxy,an amine substituted by a heteroaryl said heteroaryl optionally monosubstituted by a methyl- a C1-C6 trifluoroalkoxy,a C1-C6 alkyl,a C1-C6 trifluoroalkyl,a heteroaryl group optionally monosubstitued by a methylan aliphatic heterocycle, optionally substituted by a methyl group, a hydroxyl group, an amine group, —NHCH3, or —N(CH3)2,a C1-C6 alkyl substituted by a heterocycle, wherein said heterocycle is optionally substituted by a methyl group, a hydroxyl group, an amine group, —NHCH3, or —N(CH3)2, and/orthe fragment: a heteroaryl group, andnon aromatic monosubstituted cyclic group,and/or the pharmaceutically acceptable addition salts, solvates, Z or E isomers, enantiomers, diastereoisomers thereof, as well as mixtures thereof. |
