| 主权项 |
1. A compound of the Formula (I) wherein: Z is a bond or —N(H)—; RA is —OH, —N(H)—S(O)2—RA1, or —N(H)—S(O)2—N(H)RA1 RA1 is C1-C6 alkyl, C3-C6 cycloalkyl, or phenyl, wherein RA1 is unsubstituted or substituted by 1 to 3 fluoro or C1-C3 alkyl; the subscript n is 1, 2, 3, or 4; M is a bond or C1-C3 alkylene; ring AH is
A. phenyl; orB. a 5- to 6-membered heteroaryl containing 1 to 3 heteroatoms selected from the group consisting of N, O, and S; each R2 is independently selected from the group consisting of halo, C1-C3 alkyl, C1-C3 fluoroalkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, and —CN; the subscript b is 0, 1, 2, 3, 4, or 5; Rq1, Rq2, Rq3, and Rq4 are independently selected from the group consisting of H, halo, and C1-C3 alkyl; R1 is
A. a group of the formula —C(O)N(R3)(R4), wherein1. R3 and R4 are independently
(a.) H, or(b.) —Z—R5C, wherein
Z is a bond or C1-C3 alkylene;R5C is (i) C5-C10 mono or bicyclic carbocyclyl, (ii.) 5- to 10-membered mono- or bicyclic heterocyclyl containing 1 to 3 heteroatoms selected from N and O; (iii.) 5- to 10-membered mono or bicyclic heteroaryl containing 1 to 3 heteroatoms selected from N and O; wherein said carbocyclyl, heterocyclyl, and heteroaryl of R5C is unsubstituted or substituted by 1 to 4 R5A moieties selected from the group consisting of halo, C1-C3 alkyl, C1-C3 fluoroalkyl, C1-C3 alkoxy, and —CN; or2. R3 and R4 together with the N atom to which they are attached form R5H, wherein R5H is selected from the group consisting of: ring Ar is aryl, pyridyl, or pyrimidyl;each R7 is independently selected from the group consisting of halo, C1-C3 alkyl, C1-C3 fluoroalkyl, C1-C3 alkoxy, and —CN;each R8 is independently selected from the group consisting of H and C1-C3 alkyl;the subscript u1 is 0, 1 or 2;the subscript u2 is 0, 1, 2, or 3; orB. a moiety selected from the group consisting of: Y is a bond or C1-C3 alkylene;R6 is H, C1-C3 alkyl, or C3-C6 cycloalkyl;Rcy is:
1. C6-C10 mono or bicyclic carbocyclyl;2. 5- to 9-membered mono- or bicyclic heterocyclyl containing 1 to 3 heteroatoms selected from the group consisting of N and O;3. 5- to 9-membered mono- or bicyclic heteroaryl containing 1 to 3 heteroatoms selected N and O; wherein Rcy is unsubstituted or substituted by 1 to 3 R9 moieties which are independently selected from the group consisting of halo, C1-C3 alkyl, Cr C3 fluoroalkyl, C1-C3 alkoxy, and —CN, or wherein two R9 moieties are geminally substituted on a common ring carbon of RcY, the two geminally substituted R9 moieties, together with said common carbon atom, form —C(O)—;or a pharmaceutically acceptable salt thereof. |
