COMPOSITIONS AND METHODS FOR REGENERATION OF HARD TISSUES

摘要

Bone graft compositions including bioactive glass scaffold and characterized in that the bioactive glass scaffold has a high compressive strength, is osteoconductive and osteostimulative and resorbs at a rate consistent with the formation of new bone are described. Also, methods of using the bone grafts for regeneration of hard tissues and, especially, for treating or correcting developmental dysplasia of the hip are provided.

主权项

1. A bone graft comprising a body formed to define a predetermined configuration and comprising a resorbable, macroporous bioactive glass scaffold comprising in mass percent approximately 15-45% CaO, 30-70% SiO2, 0-25% Na2O, 0-17% P2O5, 0-10% MgO and 0-5% CaF2, wherein the bioactive glass scaffold has a compressive strength of at least approximately 17 MPa, porosity of approximately 40-60 volume percent, and pore size of approximately 5-600 microns, and the body is configured to be implanted into a prepared site in a patient's bone tissue.