| 发明名称 |
HEAT SHOCK PROTEIN (HSP) INHIBITION AND MONITORING EFFECTIVENESS THEREOF |
| 摘要 |
Provided herein are methods of treating a BRAF inhibitor resistant cancer in a subject. Also provided are methods of monitoring or evaluating the treatment of a cancer in a subject. Further provided are methods of diagnosing a cancer or disease associated with antibody production in a subject. |
| 申请公布号 |
US2015352086(A1) |
申请公布日期 |
2015.12.10 |
| 申请号 |
US201414759477 |
申请日期 |
2014.01.07 |
| 申请人 |
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. |
发明人 |
Koomen John Matthew;Smalley Keiran S.M.;Remily-Wood Elizabeth R.;Xiang Yun |
| 分类号 |
A61K31/437;G01N33/574;A61K31/46 |
主分类号 |
A61K31/437 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a BRAF inhibitor resistant or a BRAF mutant cancer in a subject, the method comprising administering to the subject a pharmaceutically effective amount of:
a) a BRAF inhibitor, and b) a heat shock protein (HSP) inhibitor, a HSP co-chaperone inhibitor, or a combination thereof. |
| 地址 |
Tampa FL US |
