发明名称 |
Double-stranded agents for delivering therapeutic oligonucleotides |
摘要 |
Disclosed are double-stranded nucleic acid agents that can deliver a therapeutic oligonucleotide within a biological sample, and methods for using the same. In one embodiment, the double-stranded nucleic acid agent comprises a first strand comprising a first RNA region, and a second strand comprising a first DNA region, wherein said first RNA region and said first DNA region are hybridized as a RNA/DNA heteroduplex. Said first strand further comprises a nucleic acid therapeutic oligonucleotide region that is capable of being cleaved from at least one nucleotide in said first RNA region. Methods for using the double-stranded nucleic acid agents include methods for delivering the therapeutic oligonucleotide as a single strand by cleaving it from at least a portion of the first RNA region. The methods further include delivering the double-stranded nucleic acid agent and thus the therapeutic oligonucleotide to a target site within the body of a treatment subject. |
申请公布号 |
AU2014272526(A1) |
申请公布日期 |
2015.12.10 |
申请号 |
AU20140272526 |
申请日期 |
2014.05.30 |
申请人 |
NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL ANDDENTAL UNIVERSITY |
发明人 |
YOKOTA, TAKANORI;NISHINA, KAZUTAKA;YOSHIOKA, KOTARO;MIZUSAWA, HIDEHIRO |
分类号 |
C12N15/09 |
主分类号 |
C12N15/09 |
代理机构 |
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