COMPOUND, COMPOSITION AND METHOD FOR TREATING AND/OR AMEOLIORATING KIDNEY DISEASE

摘要

Disclosed herein are compositions and methods for the treatment or prophylaxis of a subject having or susceptible to a kidney disease. The method includes the step of administering to the subject a compound of formula (I) in a dose of about 1 to 10 mg/Kg to improve the glomerular filtration rate (GFR) of the subject for at least 4 folds as compared to the GFR of the subject before treatment,;;The method further includes the step of administering to the subject an effective amount of lucidenic acid C (LAC), lucidenic acid N (LAN), lucidenic acid E2 (LAE2), lucidenic acid A (LAA), and lucidenic acid D2 (LAD2).

主权项

1. A pharmaceutical composition for the treatment or prophylaxis of a kidney disease comprising:
a triterpenoid compound of formula (I);lucidenic acid C (LAC), lucidenic acid B (LAB), lucidenic acid N (LAN), lucidenic acid A (LAA), lucidenic acid D2 (LAD2), lucidenic acid E2 (LAE2); and a pharmaceutically acceptable excipient;
wherein: the triterpenoid compound of formula (I) and LAC are respectively present in about 5-15% by weight of the total triterpenoid in the pharmaceutical composition, LAB and LAN are respectively present in about 5-12% by weight of the total triterpenoid in the pharmaceutical composition, LAA and LAD2 are respectively present in about 15-30% by weight of the total triterpenoid in the pharmaceutical composition, and LAE2 is present in about 8-15% by weight of the total triterpenoid in the pharmaceutical composition.