Modulators of the Interaction of Astrin and Raptor, and Uses Thereof in Cancer Therapy

摘要

The present invention relates to modulators of the interaction of astrin and raptor, and their uses in the treatment of mTOR related diseases, such as cancer.

主权项

1. A method for identifying a compound that modulates the expression, the biological activity and/or the interaction of astrin with raptor in a cell, comprising the steps of
a) contacting at least one of astrin, a raptor binding fragment of astrin, a cell expressing astrin, and/or a cell expressing a raptor binding fragment thereof with at least one compound that potentially modulates the expression, the biological activity and/or the interaction of astrin with raptor in a cell, and b) identifying a modulation of the expression and/or the binding of astrin or said fragment to raptor in the presence of said at least one compound.