CAS9-NUCLEIC ACID COMPLEXES AND USES RELATED THERETO

摘要

This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express Cas9-nucleic acid complexes disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing, diseases, conditions, cancer, viral infections or other pathogenic infection using vectors configured to express a Cas9-nucleic acid complex disclosed herein.

主权项

1. A recombinant nucleic acid comprising:
a sequence comprising a Cas9 gene, a sequence encoding an RNA, wherein the RNA comprises a first segment that is configured to bind with the Cas9 after transcription and a second segment that is configured to bind a target nucleic acid.