| 发明名称 |
APTAMER AGAINST MIDKINE AND APPLICATIONS THEREOF |
| 摘要 |
The present invention provides an aptamer binding to midkine and capable of forming a potential secondary structure represented by the formula (I):;;wherein
X1, X2, X5 and X6 are the same or different and each is one or two nucleotides selected from the group consisting of A, G, C, U and T, or a bond,X1 and X6, and X2 and X5 each form a Watson-Crick base pairs, andX3 and X4 are the same or different and each is a nucleotide selected from A, G, C, U and T. |
| 申请公布号 |
US2015353933(A1) |
申请公布日期 |
2015.12.10 |
| 申请号 |
US201314646104 |
申请日期 |
2013.11.21 |
| 申请人 |
RIBOMIC INC. ;OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
MIYAKAWA Shin;FUJIWARA Masatoshi;NAKAMURA Yoshikazu;KADOMATSU Kenji;MU Ping |
| 分类号 |
C12N15/115 |
主分类号 |
C12N15/115 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An aptamer binding to midkine and capable of forming a potential secondary structure represented by the formula (I): wherein X1, X2, X5 and X6 are the same or different and each is one or two nucleotides selected from the group consisting of A, G, C, U and T, or a bond, X1 and X6, and X2 and X5 each form a Watson-Crick base pairs, and X3 and X4 are the same or different and each is a nucleotide selected from A, G, C, U and T. |
| 地址 |
Tokyo JP |
