COMPOSITIONS AND METHODS OF REDUCING SEDATION

摘要

Provided are methods and compositions useful in reducing drug-induced sedation in subjects, wherein the compositions comprise an opioid and a dopaminergic agent. The dopaminergic agent is selected from L-DOPA, a dopamine agonist, a MAO inhibitor and a COMT inhibitor or a derivative, prodrug, ester, or pharmaceutically acceptable salt thereof. The opioid and dopaminergic agent are administered simultaneously or sequentially in the method of reducing drug-induced sedation.