| 摘要 |
The present invention provides for a topical anorectal composition, including from 10.0% (w/w) to 30.0% (w/w) of trimethylsiloxysilicate; from 1.0% (w/w) to 5.0% (w/w) at least one surfactant selected from the group consisting of sodium lauryl sulfate, alkyl- and alkoxy- dimethicone copolyol, a polysorbate, a silicone surfactant, polyalkyl & polyether modified silicone oil and a combination thereof; from 30.0% (w/w) to 75.0% (w/w) of a non-polar volatile siloxane solvent; from 0.1% (w/w) to 1% (w/w) of Natrosol thickener; from 0.05% (w/w) to 0.5% (w/w) sodium metabisulfite; from 0.25% (w/w) to 10% (w/w) of a vasoconstrictor in the form of a salt selected from the group consisting of phenylephrine hydrochloride, ephedrine sulfate and epinephrine hydrochloride, from 0.1% (w/w) to 5% (w/w) of an anesthetic selected from the group consisting of lidocaine, dibucaine, tetracaine and benzocaine; and from 15% (w/w) to 40% (w/w) of water or of a buffer of pH 4-7. |
