NEW (ACYLOXYMETHYL)ACRYLAMIDE ESTERS, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND USING THEM AS THIOREDOXIN - THIOREDOXIN-REDUCTASE SYSTEM INHIBITORS

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds of formula(1) or their pharmaceutically acceptable salts, wherein in formula (1) R1 means a linear or branched C-Calkyl group, phenyl or benzyl; R2 means hydrogen or C-Calkyl-2-formamide acetate group; R3 means acyl group of carboxylic acid specified in groups of 2,6-dichlorbenzoic or 2,6-di(trifluormethyl)benzoic acid. The invention also refers to using the compounds of formula (1) and a pharmaceutical composition containing them.EFFECT: compounds of formula (1) possessing inhibitory activity on the thioredoxin - thioredoxin-reductase system.4 cl, 2 dwg, 4 tbl