INJECTABLE FORMULATION OF NATURAL POLYSACCHARIDE AND POLYOL FOR TREATMENT OF OSTEOARTHRITIS

摘要

A sterile injectable aqueous formulation in the form of a gel made up of hyaluronic acid or a salt thereof and one or more polyols is provided. The gel formulation can be applied to the intra-articular area in the treatment of joint degeneration and osteoarthritis. The gel formulation has a rheology similar to that of synovial liquid and has an elevated resistance to degradation due to the synergistic action between the hyaluronic acid and the polyols.

主权项

1. A method of treating osteoarthritis, comprising injecting into the intra-articular space of an osteoarthritic joint an effective amount of a viscoelastic gel, the gel comprising:
hyaluronic acid or a salt thereof at a concentration of 10-25 mg/ml, the hyaluronic acid being non-cross-linked; one or more polyols at a concentration of 10-45 mg/ml; and a physiologically acceptable buffer,wherein, the gel has been moist heat sterilized.