| 发明名称 |
METHODS AND COMPOSITIONS FOR TREATING CANCER |
| 摘要 |
A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of an agent that specifically binds to or complexes with a proteolytically cleaved extracellular fragment of an immunoglobulin (Ig) superfamily cell adhesion molecule (CAM) or its receptor that is expressed by a cancer cell or another cell in the cancer cell microenvironment. The agent inhibits the cell adhesion function of the cleaved extracellular fragment or its receptor. |
| 申请公布号 |
US2015352192(A1) |
申请公布日期 |
2015.12.10 |
| 申请号 |
US201414760672 |
申请日期 |
2014.01.13 |
| 申请人 |
Case Western Reserve University |
发明人 |
BRADY-KALNAY Susann |
| 分类号 |
A61K38/46;A61N5/10;A61K45/06 |
主分类号 |
A61K38/46 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of an agent that specifically binds to or complexes with a proteolytically cleaved extracellular fragment of an immunoglobulin (Ig) superfamily cell adhesion molecule (CAM) or its receptor that is expressed by a cancer cell or another cell in the cancer cell microenvironment, wherein the agent inhibits the cell adhesion function of the cleaved extracellular fragment or its receptor. |
| 地址 |
Cleveland OH US |
