| 发明名称 |
Notch Ligand Bound Biocompatible Substrates And Their Use In Bone Formation |
| 摘要 |
Disclosed herein are compositions comprising an osteoinductive Notch ligand bound to at least one biocompatible substrate. Also disclosed are methods of treating patients in need of bone tissue formation through the administration of a composition comprising an osteoinductive Notch ligand bound to at least one biocompatible substrate. Further provided are methods of treating a patient in need of bone tissue formation comprising administering to said patient a composition comprising a nucleic acid molecule encoding a notch intracellular domain (NICD). Also disclosed are kits for promoting bone tissue formation. |
| 申请公布号 |
US2015352180(A1) |
申请公布日期 |
2015.12.10 |
| 申请号 |
US201414760371 |
申请日期 |
2014.01.10 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
HANKENSON KURT DAVID;DISHOWITZ MICHAEL IRVING;BURDICK JASON ALAN;ZHU FENGCHANG;AHN JAIMO |
| 分类号 |
A61K38/17;A61K47/42;A61K47/02;A61K47/48;A61K35/28 |
主分类号 |
A61K38/17 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An implantable composition comprising: an osteoinductive Notch ligand bound to at least one biocompatible substrate. |
| 地址 |
Philadelphia PA US |
