| 发明名称 |
SONOSENSITIVE LIPOSOME, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND METHOD OF DELIVERING ACTIVE AGENT TO SUBJECT USING THE SONOSENSITIVE LIPOSOME |
| 摘要 |
Provided is a liposome comprising a lipid bilayer and a sonosensitizer that is disposed in and/or on the lipid bilayer, wherein the sonosensitizer self-assembles to form aggregates when exposed to ultrasound; and a method of efficiently delivering an active agent to a target site in the body of a subject using the sonosensitive liposome. |
| 申请公布号 |
US2015352039(A1) |
申请公布日期 |
2015.12.10 |
| 申请号 |
US201514830503 |
申请日期 |
2015.08.19 |
| 申请人 |
Samsung Electronics Co., Ltd. |
发明人 |
PARK Sun Min;NAM Jungyong;PARK Kitae;KIM Hyun Ryoung;PARK Eun Sung |
| 分类号 |
A61K9/00;A61K31/704;A61K47/26;A61K9/127 |
主分类号 |
A61K9/00 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A liposome comprising:
a lipid bilayer; and a sonosensitizer that is disposed in and/or on the lipid bilayer, wherein the sonosensitizer self-assembles to form aggregates when exposed to ultrasound, and wherein the sonosensitizer has a structural formula of wherein C1 is a C8-C40 alkyl group, B1 is —NH—C(O)—NH—, —O—C(O)—, —NH—C(O)—,—CH(COOH)—, or —NH—C(O)—O—, and D1 is |
| 地址 |
Suwon-si KR |
