Enteric Soft Capsules

摘要

A gel mass is provided that is useful in manufacturing enteric soft or hard capsules, or enteric tablets without coating.

主权项

1. An enteric soft capsule shell formed from a gel mass comprising:
(a) a gelatin, (b) an acid-insoluble polymer; and (c) an alkaline aqueous solvent; wherein the gelatin and acid-insoluble polymer together comprise 45% by weight of the gel mass; the ratio of acid-insoluble polymer to gelatin is from 30:70 to 45:55 by weight; the final pH of the gel mass is less than or equal to about 9 pH units; and the final moisture content of the enteric soft capsule shell formed from the gel mass composition is from about 2% to about 10%.