| 摘要 |
FIELD: chemistry.SUBSTANCE: first polymer carrier with grafted biological vector and chelate units for radiometal binding is obtained. Then, procedure of radio-marking is carried out. Interaction of polymer carrier of chelate units with radioactive component is carried out in alcohol, in water or water-alcohol solution in inert gas atmosphere at temperature 70°C for 20 minutes. As polymer carrier applied is water-soluble copolymer of N-vinylpyrrolidone with N-allylamine with molecular weight 5000-50000 Da, content of chelate units in from of iminodiacetate fragments of iminodiacetic acid 1-20 mol %, content of vinylpyrrolidone m = 99-80 mol % and allylamine n = 1-20 mol %. As radioactive component applied are compounds of transition metals and lanthanides in form of following line [Tc(CO)], [Re(CO)], [Tb(CO)].EFFECT: invention makes it possible to obtain hybrid water-soluble highly-molecular carriers of radioisotopes with high output, without requiring additional purification of final product.4 dwg, 1 tbl, 5 ex |
