USE OF LYMPHOCYTE ACTIVATION GENE 3 (LAG-3) EXPRESSION PROFILING AS A BIOMARKER FOR ASSESSING INFLAMMASOMES, CHRONIC INFLAMMATORY DISEASES AND DYSFUNCTIONAL HDL

摘要

A method for determining whether a subject has or is predisposed to abnormal expression of inflammasomes and/or to dysfunctional HDL suitable for use in diagnosing atherosclerosis, chronic inflammatory disease, Incident Cardiovascular Disease (ICD) and other pathologies characterized by an inflammatory response. Specifically, a protein assay that measures LAG-3 can be used as a diagnostic predictor of pathologies such as infection, inflammation, chronic inflammatory disease, and coronary artery disease. The diagnostic is combined with the therapeutic use of a remediating drug for treatment.

主权项

1. A method for detecting dysfunctional HDL cholesterol (HDL-C) in a subject, comprising the steps of:
detecting the level of soluble lymphocyte activation gene 3 (sLAG-3) in a sample from the subject; and comparing the level of sLAG3 in the sample with the level of sLAG3 in a control sample, wherein a decrease in the level of sLAG-3 indicates the presence of dysfunctional HDL-C in the subject.