发明名称 |
DIAGNOSIS OF A NEUROLOGICAL DISEASE |
摘要 |
The present invention relates to a method for diagnosing a disease, comprising the step detecting in a sample an autoantibody binding to the alpha 3 subunit of the human neuronal Na(+)/K(+) ATPase, an isolated and/or recombinant polypeptide comprising the alpha 3 subunit of the human neuronal Na(+)/K(+) ATPase, a use of a membrane-associated human Na(+)/K(+) ATPase or a variant thereof for the diagnosis of a disease, an isolated and/or recombinant polypeptide comprising the alpha 3 subunit of the human neuronal Na(+)/K(+) ATPase or a variant thereof, for use in the treatment of a disease, an autoantibody binding to said polypeptide and a method for isolating such autoantibody, a pharmaceutical composition, medical or diagnostic device or test kit comprising the polypeptide. |
申请公布号 |
US2015355177(A1) |
申请公布日期 |
2015.12.10 |
申请号 |
US201514729609 |
申请日期 |
2015.06.03 |
申请人 |
EUROIMMUN Medizinische Labordiagnostika AG |
发明人 |
KOMOROWSKI Lars;SCHARF Madeleine;MISKE Ramona;DENNO Yvonne;DETTMANN Inga-Madeleine;PROBST Christian;HEIDENREICH Fedor;GIEß Ralf |
分类号 |
G01N33/564;C07K16/40;C12N9/14 |
主分类号 |
G01N33/564 |
代理机构 |
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代理人 |
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主权项 |
1. A method for diagnosing a disease, comprising the step detecting in a sample an autoantibody binding to the alpha 3 subunit of the human neuronal Na(+)/K(+) ATPase. |
地址 |
Lübeck DE |