| 发明名称 |
Mait-like Cells and Method for Manufacturing Same |
| 摘要 |
The object of the present invention is to provide a method for preparing induced pluripotent stem cells from MAIT cells, and providing induced pluripotent stem cells derived from MAIT cells. Another object of the present invention is to provide a method for preparing MAIT-like cells from induced pluripotent stem cells, and providing MAIT-like cells. Differentiation of the induced pluripotent stem cells having a MAIT cell-specific TCR gene can be induced to establish MAIT-like cells. |
| 申请公布号 |
US2015353889(A1) |
申请公布日期 |
2015.12.10 |
| 申请号 |
US201314439187 |
申请日期 |
2013.10.30 |
| 申请人 |
DAIICHI SANKYO COMPANY, LIMITED ;NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY |
发明人 |
WAKAO Hiroshi;FUJITA Hiroyoshi;KOSHIMIZU Uichi;YOSHIKIYO Kazunori |
| 分类号 |
C12N5/0783;A61K35/17 |
主分类号 |
C12N5/0783 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing a MAIT-like cell comprising differentiating an induced pluripotent stem cell that was reprogrammed from a MAIT cell by a reprogramming factor, wherein the induced pluripotent stem cell retains a TCR α chain gene rearranged to a MAIT cell-specific fashion. |
| 地址 |
Tokyo JP |
