Multi-Component Crystalline Particles for Inhalation Therapy

摘要

Pharmaceutical Preparations Multi-component crystalline particles and compositions, methods for their preparation, their uses in inhalation therapy and inhaler devices containing said particles are provided, in particular particles comprising glycopyrrolate. The particles can be prepared substantially free of excipients and agents other than active agents or their precursors in the presence of ultrasonic irradiation in a process comprising contacting a solution in a first flowing stream with an anti-solvent in a re-circulating second flowing stream, causing the mixing thereof and collecting crystals that are generated.

主权项

1. Multi-component crystalline particles for inhalation therapy comprising glycopyrrolate and a long-acting β2 adrenergic receptor agonist (LABA), including any pharmaceutically acceptable salts, esters, isomers or solvates thereof, wherein the particles are substantially free of excipients and agents other than active agents and wherein the particles are prepared in the presence of ultrasonic irradiation in a process comprising contacting a solution in a first flowing stream with an anti-solvent in a re-circulating second flowing stream, causing the mixing thereof and collecting crystals that are generated.