METHOD AND COMPOSITION FOR CANCER DISEASE TREATMENT, TOSYLATE AND PHARMACEUTICALLY ACCEPTABLE SALTS OF N-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)-N'-(4-(2-(N-METHYLCARBAMOYL)-4-PYRIDYLOXY)PHENYL)UREA

摘要

FIELD: medicine. ^ SUBSTANCE: invention relates to arylurea derivatives useful in treatment of raf kinase-mediated diseases such as cancer. Claimed composition contains therapeutically effective amount of raf kinase inhibitor, namely pharmaceutically acceptable salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea, in particular N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea tosylate. ^ EFFECT: agent for cancer treatment of increased activity. ^ 11 cl, 5 dwg, 5 ex