发明名称 |
NANOPARTICLE DRUG DELIVERY SYSTEMS |
摘要 |
The invention provides pharmaceutical compositions and method of using the compositions, wherein the compositions comprise liposomes or micelles that contain one or more targeting peptides and/or anticancer drugs. In various embodiments, the components of the liposomes can include a) a phospholipid and optionally a lipid that is not a phospholipid; b) a pegylated lipid; c) a peptide-ethylene glycol (EG)-lipid conjugate wherein the peptide is a targeting ligand, and d) one or more drug-conjugated lipid, encapsulated drugs, or a combination thereof. The peptide-EG-lipid conjugate can be, for example, a compound of Formula (I) or Formula (II). The ethylene glycol (EG) segments of the peptide-EG-lipid conjugate can be, for example, EG6 to about EG36; and the EG segment can be conjugated to one or more lysine moieties. |
申请公布号 |
EP2950785(A2) |
申请公布日期 |
2015.12.09 |
申请号 |
EP20140746863 |
申请日期 |
2014.02.04 |
申请人 |
UNIVERSITY OF NOTRE DAME DU LAC |
发明人 |
BILGICER, ZIHNI BASAR;ASHLEY, JONATHAN;KIZILTEPE-BILGICER, TANYEL;STEFANICK, JARED;ALVES, NATHAN |
分类号 |
A61K47/48;A61K9/127;A61K9/48;A61K38/00;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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