MODIFIED STARCH DERIVATIVE-BASED MATRIX FOR COLON TARGETING

摘要

The invention provides a controlled-release oral pharmaceutical composition of at least an active agent, comprising:
a) a lipophilic matrix consisting of lipophilic compounds and/or amphiphilic compounds;
b) an hydrophilic matrix,
wherein the hydrophilic comprises at least an indigestible polysaccharide, the active ingredient being dispersed in the lipophilic and/or the hydrophilic matrix.
The present invention also relates to a process for the preparation of such a pharmaceutical composition.