BRAIN-MIGRATING POLYPEPTIDE HAVING POLYVALENT BOND AND IMPROVED METABOLIC STABILITY

摘要

Disclosed is a brain-migrating polypeptide having a reactive group for binding to a molecule having no brain-migrating activity, which is produced by introducing at least two lysine residues into a circularized polypeptide having a brain-migrating motif sequence. The polypeptide is improved in metabolic stability compared to a conventional brain-migrating polypeptide, and enables the migration of a desired molecule into the brain with high efficiency.