发明名称 |
COMPOSITION FOR TREATMENT OF PATHOGENS THAT ARE RESISTANT TO TETRACYCLINES |
摘要 |
The invention relates to compounds and pharmaceutical compositions useful in combination with tetracyclines in the treatment of bacterial infections caused by Gram-positive and Gram-negative pathogens, with particular efficacy in tetracycline resistant strains. These compounds specifically bind to TetR and therefore prevent the transcriptional activation of tet resistance genes. The compounds have a potentiating effect on the activity of members of the tetracycline family, in particular of tetracycline, minocycline, doxycycline and tigecycline, in the treatment of tetracycline susceptible, intermediate and tetracycline resistant pathogens. |
申请公布号 |
EP2950793(A1) |
申请公布日期 |
2015.12.09 |
申请号 |
EP20140703052 |
申请日期 |
2014.02.03 |
申请人 |
BIOVERSYS AG |
发明人 |
SCHNEIDER, PETER;RIEDL, RAINER;TIGGES, MARCEL;GITZINGER, MARC;PIEREN, MICHEL;LEVI, ASSAF;SEPHTON, MARK;SCHELLHORN, BIRGIT;ZUEGER, PATRIK;BRAND, MICHAEL;GYGAX, DANIEL;SPIES, PETER |
分类号 |
A61K31/16;A61K31/165;A61K31/166;A61K31/167;A61K31/4965;A61P31/00;C07C231/00;C07C233/58;C07C233/64;C07C235/46;C07D241/02 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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