| 摘要 |
<p>A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801).</p> |
| 申请人 |
ONYX PHARMACEUTICALS, INC. |
发明人 |
KERSCHEN, JAMES, ALAN;BRIDGES, ALEXANDER, JAMES;DALZIEL, SEAN, MARK;DAPREMONT, OLIVIER;KIM, HYUNJUNG;THOMPSON, ANDREW, S.;ZELLER, JAMES, ROBERT |
