IMPROVED METHOD FOR PREPARING (R)-9-[2-(PHOSPHONOMETHOXY)PROPYL]ADENINE

摘要

The present invention relates to a method for preparing high purity (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA), According to the present invention, the method uses dialkyl methylsulfonyl-oxymethyl phosphonate, which generates only a small amount of impurities in a reaction and has high purity, as an intermediate to prepare the high purity PMPA with a small amount of impurities. The present invention does not use a reagent sensitive to air and moisture contact to enhance safety and allow reproducible production and is easily handled to enable mass production. The high purity PMPA prepared by using the method can be used to prepare tenofovir disoproxil and acidic salt thereof in order to give a very favorable advantage for the production of high quality drug ingredient.