发明名称 |
METHOD FOR PROMOTING DIFFERENTIATION OF MESENCHYMAL STEM CELLS TO CHONDROCYTES USING POROUS 3 DIMENSIONAL SCAFFOLD |
摘要 |
The present invention relates to a method for specifically differentiating mesenchymal stem cells into chondrocytes using a porous three dimensional laminated support, to a porous three dimensional laminated support containing the chondrocytes differentiated by the method, and to a therapeutic agent for arthritis including the support. According to the present invention, provided is a tissue engineering method which can specifically differentiate the mesenchymal stem cells into chondrocytes by using a simple and efficient method without using a separate medium designed to induce differentiation of chondrocytes. The porous three dimensional laminated support containing the mesenchymal stem cells prepared by the method of the present invention has a stable three dimensional structure, and an excellent interconnectivity between air gaps, so oxygen and nutrients required for survival and growth of a cell are smoothly suppled. Therefore, the porous three dimensional laminated support of the present invention has an excellent cell survival rate, thereby being usefully used as a therapeutic agent for arthritis and cell growth plates. |
申请公布号 |
KR20150137341(A) |
申请公布日期 |
2015.12.09 |
申请号 |
KR20140065031 |
申请日期 |
2014.05.29 |
申请人 |
SNU R&DB FOUNDATION;RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY |
发明人 |
LEE, EUN JU;KIM, GEUN HYUNG;PARK, JONG NAM;LEE, JI YEON;AHN, SEUNG HYUN;LEE, HYEONG JIN |
分类号 |
C12M3/00;C12N5/071;C12N5/0775 |
主分类号 |
C12M3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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