发明名称 |
METHODS AND COMPOSITIONS RELATED TO MIR-21 AND MIR-29A, EXOSOME INHIBITION, AND CANCER METASTASIS |
摘要 |
The present invention provides materials and methods related to the discovery that tumor secreted miR-21 and miR-29a can function by binding as ligands to receptors of the Tolllike receptor family, murine TLR7 and human TLR8, in immune cells, triggering a TLR-mediated prometastatic inflammatory response, which leads to tumor growth and metastasis. Thus, by acting as paracrine agonists of TLRs, secreted miRNAs are key regulators of the tumor microenvironment. This mechanism of action of miRNAs is important in the tumor-immune system communication, in tumor growth and spread, and in cancer treatment. |
申请公布号 |
EP2790735(A4) |
申请公布日期 |
2015.12.09 |
申请号 |
EP20120857918 |
申请日期 |
2012.12.13 |
申请人 |
OHIO STATE INNOVATION FOUNDATION |
发明人 |
CROCE, CARLO, M.;FABBRI, MULLER |
分类号 |
A61K48/00;C07H21/02;C12N5/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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地址 |
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