摘要 |
In accordance with this invention a novel pharmaceutical product containing efavirenz, emtricitabine and tenofovir DF are provided as a multicomponent unitary oral dosage form, component 1 comprising tenofovir DF (and, optionally, emtricitabine) and component 2 comprising efavirenz, wherein components 1 and 2 are in a stabilizing configuration. In preferred embodiments component 1 is made by dry granulation. |
申请人 |
BRISTOL-MYERS SQUIBB & GILEAD SCIENCES, LLC |
发明人 |
DAHL, TERRENCE, C.;HUSSAIN, MUNIR, A.;LIPPER, ROBERT, A.;JERZEWSKI, ROBERT, L.;MENNING, MARK, M.;OLIYAI, REZA;YANG, TAIYIN |