发明名称 TRAIL MEMBRANE-PENETRATING PEPTIDE-LIKE MUTANT, METHOD OF PREPARING SAME, AND USE THEREOF
摘要 The invention mainly relates to the field of genetic engineering drugs, in particular to a mutant cDNA sequence obtained by mutating valine at position 114, glutamate at position 116, glycine at position 118, proline at position 119 and glutamine at position 120 in an amino acid sequence at positions 114-281 of an extracellular fragment of a wild-type TRAIL protein respectively into arginines, so as to allow amino acids at positions 114-121 of the TRAIL protein to form a 8-consecutive arginine sequence, and then by gene synthesis and PCR mutation and splicing; and the TRAIL mutant has excellent therapeutic effect for a variety of tumors of different types, and is a new generation of promising drug for highly efficiently inducing tumor cell apoptosis.
申请公布号 EP2952523(A1) 申请公布日期 2015.12.09
申请号 EP20140877744 申请日期 2014.10.10
申请人 CHENGDU HUACHUANG BIOTECHNOLOGY CO., LTD 发明人 CHEN, SHOUCHUN;YAN, JUAN;XU, QI;HU, HAIYANG;HUANG, XIANZHOU;WEI, LIJIA
分类号 C07K14/705;A61K38/17;A61P35/00;C12N15/10;C12N15/12;C12N15/70 主分类号 C07K14/705
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